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The effect of acebutolol and propranolol on the hypoglycaemic action of glibenclamide.
Author(s) -
Zaman R,
Kendall MJ,
Biggs PI
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01412.x
Subject(s) - acebutolol , glibenclamide , propranolol , tolbutamide , medicine , pharmacology , action (physics) , endocrinology , diabetes mellitus , physics , quantum mechanics
1 The effect of acebutolol, a relatively selective beta‐adrenoceptor blocking drug and propranolol, a non‐selective one, on the hypoglycaemic action of glibenclamide after an oral glucose load has been investigated in a group of maturity‐onset diabetic patients. 2 Glibenclamide significantly reduced the blood glucose levels and both acebutolol and propranolol, at therapeutic doses, were found to modify this action significantly. 3 The effect of acebutolol was slightly less than that of propranolol. The difference was not statistically significant. 4 The modes of action of sulphonylureas are reviewed and it is suggested that beta‐adrenoceptor blockers may modify their effect on insulin release. This appears to be a drug interaction rather than an effect of beta‐adrenoceptor blockade on glucose tolerance.