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Bioavailability of diazepam after intravenous, oral and rectal administration in adult epileptic patients.
Author(s) -
Dhillon S,
Oxley J,
Richens A
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01397.x
Subject(s) - suppository , diazepam , rectal administration , medicine , anticonvulsant , bioavailability , anesthesia , oral administration , absorption (acoustics) , rectum , pharmacology , epilepsy , gastroenterology , physics , psychiatry , acoustics
1 The absorption of single doses of diazepam in six adult epileptic subjects following intravenous, oral and rectal administration were studied in order to evaluate the usefulness of the latter in emergency situations in the adult. 2 Diazepam tablets (Valium, Roche) and rectal solution (Valium solution for intravenous administration) produced similar peak serum concentrations after delays of 15‐90 min. 3 Two suppository formulations showed statistically significant differences in absorption characteristics. 4 Serum diazepam levels above 400 ng ml‐ 1 (suggested to be necessary for a satisfactory anticonvulsant effect) were reached in only a few subjects after rectal doses of 10‐20 mg of solution, and then usually after a delay of over 2 h.