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Antihypertensive effects of lofexidine in patients with essential hypertension.
Author(s) -
Fagan TC,
Bloomfield SS,
Cowart TD,
CornsHurwitz RH,
Lipicky RJ,
Conradi EC,
Hsu CY,
Grossman WJ,
Harmon GE,
Degenhart WJ,
Sinkfield AW,
Gaffney TE
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01393.x
Subject(s) - orthostatic vital signs , medicine , supine position , clonidine , essential hypertension , blood pressure , anesthesia , heart rate , sedation , mean arterial pressure , pharmacology
1 Single oral doses of lofexidine, 0.1, 0.3, and 0.6 mg produced dose related decreases in supine and standing arterial pressure and heart rate in nineteen patients with essential hypertension. 2 A mean oral antihypertensive threshold dose of less than 0.1 mg was estimated. 3 Lofexidine decreased mean urinary noradrenaline excretion 28% and caused significant retention of sodium and water. 4 The most prominent side effects were sedation and orthostatic dizziness. 5 Lofexidine is pharmacologically similar to, but apparently less potent than clonidine as an antihypertensive agent.