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Comparison of the pharmacodynamic and pharmacokinetic profiles of single and multiple doses of a commercial slow‐release metoprolol formulation with a new Oros delivery system.
Author(s) -
Kendall MJ,
Jack DB,
Woods KL,
Laugher SJ,
Quarterman CP,
John VA
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01391.x
Subject(s) - metoprolol , pharmacokinetics , dosing , pharmacodynamics , pharmacology , hemodynamics , medicine , delivery system , anesthesia
1 A new osmotic pressure mediated delivery system for metoprolol (Lopresor Oros) has been evaluated by measuring the haemodynamic effects and pharmacokinetics after single and multiple oral dosing in young healthy volunteers. 2 Similar studies have been carried out in the same group using equivalent single and multiple oral doses of the commercial slow‐release preparation (Slow Lopresor). 3 The new osmotic delivery system produces a more uniform haemodynamic response: a plateau metoprolol concentration in plasma is reached about 6 h after dosing and is maintained for 10 h.