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Effect of rifampicin on metoprolol and antipyrine kinetics.
Author(s) -
Bennett PN,
John VA,
Whitmarsh VB
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01390.x
Subject(s) - metoprolol , rifampicin , pharmacokinetics , elimination rate constant , pharmacology , beta (programming language) , medicine , oral administration , plasma concentration , chemistry , tuberculosis , volume of distribution , computer science , programming language , pathology
1 Effects of rifampicin on the pharmacokinetics of single oral doses of metoprolol and antipyrine are reported. 2 Rifampicin, administered daily for 15 days, reduced the area under the plasma concentration‐time curve (AUC) of metoprolol but the rate constant for elimination (beta) of metoprolol from plasma did not alter significantly. 3 Administration of rifampicin for 13 days reduced AUC and increased beta of antipyrine. Thirteen days after discontinuing rifampicin. AUC and beta of antipyrine remained significantly different from the initial values. 4 Some loss of beta‐adrenoceptor blockade should be anticipated if rifampicin is administered to patients who are receiving metoprolol.