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Increased levels of 6‐oxo‐PGF1 alpha in human skin following ultraviolet B irradiation.
Author(s) -
Black AK,
Hensby CN,
Greaves MW
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01385.x
Subject(s) - erythema , alpha (finance) , irradiation , medicine , human skin , dermatology , chemistry , nuclear medicine , biology , surgery , physics , construct validity , genetics , nuclear physics , patient satisfaction
1 Clinically normal human abdominal skin in 11 subjects, was irradiated with three times the minimal‐erythema dose of ultraviolet B (u.v. B) irradiation. 2 Erythema was assessed visually, and exudate was recovered by a suction bulla technique from normal skin, and from skin at 6, 24 and 48 h after irradiation. 3 Erythema was moderate at 6 h, but increased to a maximum at 24 h, which was maintained at 48 h. 4 6‐ oxo‐PGF1 alpha was markedly raised at 6 h, moderately raised at 24 h, but had returned to control levels at 48 h, when the erythema was still maximal. 5 Prostaglandin I2, the precursor of 6‐oxo‐PGF1 alpha and 6‐ oxo‐PGF1 alpha may, therefore, play a part in the early inflammatory process after u.v. B irradiation, but is unlikely to be responsible for the erythema still present at 48 h.