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Antihypertensive action of acebutolol (Sectral) when used concomitantly with hydrochlorothiazide.
Author(s) -
Mitenko PA,
McKenzie JK,
Brossard JJ
Publication year - 1982
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1982.tb01358.x
Subject(s) - acebutolol , hydrochlorothiazide , supine position , medicine , blood pressure , placebo , anesthesia , alternative medicine , pathology
1 In a placebo‐controlled study, the respective anti‐hypertensive effects of hydrochlorothiazide and hydrochlorothiazide plus the beta‐ adrenoceptor blocker acebutolol were assessed in 18 patients with moderately severe essential hypertension. 2 Hydrochlorothiazide 100 mg daily decreased the mean supine blood pressures from 163/107 mmHg to 150/103 mmHg. Addition of acebutolol in a single‐blind fashion in doses up to 800 mg daily reduced mean supine pressure to 137/95 mmHg. Further increases in acebutolol dosage to a maximum of 2000 mg daily in 13 patients whose hypertension was not well controlled on lower doses resulted in a mean supine blood pressure of 132/92 mmHg.