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Factors influencing the activity and fate of benzodiazepines in the body.
Author(s) -
van der Kleijn E,
Vree TB,
Baars AM,
Wijsman R,
Edmunds LC,
Knop HJ
Publication year - 1981
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1981.tb01843.x
Subject(s) - pharmacokinetics , glucuronidation , pharmacology , medicine , clinical pharmacology , chemistry , biochemistry , enzyme , microsome
1 The clinical pharmacokinetics of the many benzodiazepines used to treat numerous and varied clinical conditions can be influenced by many factors. 2 Combinations of drugs efficacious in the central nervous system can change the onset, intensity and duration of effect as a result of pharmacological, physiological and pharmacokinetic actions. 3 Pharmacokinetic considerations indicate that short to medium long‐ acting benzodiazepines that depend on only glucuronidation for their major metabolic pathway are the drugs of choice in this category.