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An oral buprenorphine and paracetamol combination compared with paracetamol alone: a single dose double‐blind postoperative study.
Author(s) -
Bullingham RE,
McQuay HJ,
Moore RA,
Weir L
Publication year - 1981
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1981.tb01322.x
Subject(s) - buprenorphine , medicine , analgesic , anesthesia , acetaminophen , opiate , double blind , opioid , placebo , receptor , alternative medicine , pathology
1 An oral combination of buprenorphine and paracetamol was compared with paracetamol alone in a single dose, double‐blind postoperative study. One hundred and twenty patients undergoing elective minor orthopaedic operations were allocated to four groups of 30 patients. The four treatments were 1,1.5 or 2 mg of buprenorphine with paracetamol 1,000 mg or paracetamol 1,000 mg alone. 2 There were no significant differences between the groups in analgesia measured by the observer over the 6 h period of direct observations. The oral opiate produced a significant increase in duration of analgesia beyond the 6 h study period. A significant increase in side‐effects was seen only at the highest buprenorphine dose compared with paracetamol. 3 The problems of trial design for analgesic combinations are considered. Drug mixtures create additional complexities which decrease the certainty of the conclusion that no real benefits result from such mixtures.