Premium
Cerebrospinal fluid concentrations of propranolol, pindolol and atenolol in man: evidence for central actions of beta‐adrenoceptor antagonists.
Author(s) -
Taylor EA,
Jefferson D,
Carroll JD,
Turner P
Publication year - 1981
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1981.tb01264.x
Subject(s) - atenolol , pindolol , propranolol , cerebrospinal fluid , medicine , adrenergic beta antagonists , beta (programming language) , adrenergic receptor , pharmacology , beta adrenoceptor , endocrinology , anesthesia , blood pressure , receptor , computer science , programming language
1 Single and multiple oral dose studies of the penetration into CSF of three beta‐adrenoceptor antagonists were performed in groups of patients needing lumbar puncture as part of their neurological investigation. Propranolol, pindolol and atenolol were chosen because of their differing physico‐chemical properties. 2 The CSF concentration of propranolol (lipid‐soluble) and pindolol (moderately lipid‐soluble) was proportional to the free plasma concentration and was similar to, although generally lower than, that theoretically predicted. 3 The CSF concentrations of the poorly lipid‐soluble atenolol were similar in different patients and were independent of plasma concentration. This may be due to the slow rate of diffusion of atenolol into CSF preventing the predicted concentrations being achieved.