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Long‐term cyclophosphamide treatment in rheumatoid patients: effects on serum sulphydryl levels, technetium index, ESR and clinical response.
Author(s) -
Grimaldi MG
Publication year - 1981
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1981.tb01257.x
Subject(s) - cyclophosphamide , erythrocyte sedimentation rate , technetium , medicine , rheumatoid arthritis , therapeutic index , immunology , gastroenterology , clinical disease , pharmacology , endocrinology , chemotherapy , disease , nuclear medicine , drug
1 After 12 months cyclophosphamide administration the serum sulphydryl concentrations increased in all of twelve rheumatoid patients treated, and returned towards the normal range in eleven. 2 A decrease was observed in the technetium index, the erythrocyte sedimentation rate, and joint count. 3 Long‐term cyclophosphamide‐induced serum SH increase may represent a specific change in the process of the rheumatoid disease activity, possibly involving the pathogenic B cells.