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Effects of salbutamol, ipratropium bromide and disodium cromoglycate on breathlessness induced by exercise in normal subjects.
Author(s) -
Stark RD,
Gambles SA
Publication year - 1981
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1981.tb01256.x
Subject(s) - ipratropium bromide , salbutamol , medicine , inhalation , anesthesia , ventilation (architecture) , disodium cromoglycate , respiratory system , respiratory minute volume , bronchodilator , asthma , mechanical engineering , engineering
1 Healthy volunteers undertook submaximal graded exercise while objective measurements of cardio‐respiratory function were made and breathlessness was assessed with serial visual analogue scales. 2 A useful and consistent relationship existed between breathlessness and ventilation for individual subjects. 3 Drugs were examined in this system to test whether they modified the relationship between ventilation and breathlessness such that less breathlessness occurred for a given level of ventilation. 4 Salbutamol, ipratropium bromide and disodium cromoglycate given by inhalation did not reduce breathlessness in healthy subjects during exercise.