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Once daily beta‐adrenoceptor blockade in hypertension: an ambulatory assessment.
Author(s) -
Mann S,
Craig MW,
Balasubramanian V,
Raftery EB
Publication year - 1981
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1981.tb01204.x
Subject(s) - pindolol , medicine , sotalol , dosing , blood pressure , regimen , ambulatory blood pressure , ambulatory , anesthesia , heart rate , crossover study , propranolol , alternative medicine , pathology , placebo , atrial fibrillation
1 The ambulant intra‐arterial blood pressure of eighteen hypertensive subjects was monitored before and again after 3 months treatment with thrice daily sotalol (six patients), twice daily pindolol (six patients) and once daily pindolol (six patients). 2 Three patients in the sotalol group underwent a third study having changed to a once daily regimen; similarly six patients in the pindolol groups were restudied having crossed over to the alternative pindolol dosing regimen, total daily dosage being maintained in all cases. 3 Comparison of 24 h blood pressure curves before and after treatment showed effective daytime reduction but less consistent effects at night. 4 In the crossover experiments once daily and multiple daily dosing regimens produced identical patterns of reduction over 24 h in both blood pressure and heart rate. 5 It is inferred that in the treatment of hypertension, once daily dosing with standard preparations of beta‐ adrenoceptor blocking agents is probable adequate.