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Comparison of four different beta‐adrenoceptor blocking drugs on lymphocyte isoprenaline‐stimulated cyclic AMP production.
Author(s) -
Lima DR,
Kilfeather S,
Hedges A,
Turner P
Publication year - 1981
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1981.tb01170.x
Subject(s) - pindolol , acebutolol , atenolol , isoprenaline , partial agonist , medicine , endocrinology , stimulation , agonist , chemistry , propranolol , lymphocyte , timolol , intrinsic activity , pharmacology , receptor , blood pressure , intraocular pressure , ophthalmology
1 The influence of acebutolol, atenolol, pindolol and timolol on human lymphocyte cyclic AMP (cAMP) and its stimulation by isoprenaline in vitro has been studied. 2 Acebutolol and atenolol (10(‐8)‐10(‐6)M) had no significant influence on lymphocyte cAMP levels or on isoprenaline‐ stimulated increase in cAMP. 3 Pindolol and timolol significantly antagonised the effect of isoprenaline, and pA2 values were calculated to be 8.12 and 8.04 respectively. This suggests that beta 2‐ adrenoceptors are involved in this phenomenon. 4 Only pindolol produced a significant increase in lymphocyte cAMP, which is consistent with its partial agonist activity.