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Total and free serum haloperidol levels in schizophrenic patients and the effect of age thioridazine and fatty acid on haloperidol‐serum protein binding in vitro.
Author(s) -
Rowell FJ,
Hui SM,
Fairbairn AF,
Eccleston D
Publication year - 1981
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1981.tb01135.x
Subject(s) - haloperidol , thioridazine , endocrinology , radioimmunoassay , volunteer , chemistry , medicine , pharmacology , chlorpromazine , biology , dopamine , agronomy
1 Using radioimmunoassays, steady‐state levels of total and free haloperidol (obtained by ultrafiltration and dialysis) have been determined in twenty‐two patients on long term treatment receiving doses from 3 to 45 mg per day. 2 For the group, both total serum concentration and free drug concentration showed significant correlations (P less than 0.001) with daily dose. 3 No significant correlation was observed between age of the patient and percentage free haloperidol in serum. 4 In vitro experiments using sera from twenty‐ three healthy volunteers showed significant negative correlations (P less than 0.01) between age and percentage free haloperidol. 5 Thioridazine and oleic acid significantly enhanced the percentage of free haloperidol in normal human sera in vitro.