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Further evidence for an acetylator phenotype difference in the metabolism of hydralazine in man.
Author(s) -
Facchini V,
Timbrell JA
Publication year - 1981
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1981.tb01131.x
Subject(s) - hydralazine , urine , metabolism , chemistry , phenotype , phthalazine , endocrinology , pharmacology , medicine , chromatography , biochemistry , blood pressure , medicinal chemistry , gene
1 The 0‐24 h urine from hypertensive patients treated with hydralazine (100 mg twice daily) has been analysed by gas chromatography and high pressure liquid chromatography. 2 4‐N‐Acetylhydrazinophthalazine‐1‐one (NAcHPZ), s‐triazolo [3, 4‐a] phthalazine (TP), phthalazinone (PZ) and hydralazine (free, H; acid‐labile hydrazones, HH) were detected and assayed. 3 The results indicate that slow acetylators excrete less NAcHPZ and TP than rapid acetylators but more PZ and HH. 4 Free hydralazine was present in low levels and was only detected in some urine samples. 5 The ratios of the metabolites NAcHPZ/HH; TP/HH; NAcHPZ/PZ and PZ/TP are different in the two acetylator phenotypes. 6 It is possible the ratio PZ/TP may be used for determination of acetylator phenotype. 7 It is concluded that hydralazine metabolism is dependent on the acetylator phenotype.