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Inhibition of gastric acid secretion with a mast cell stabiliser, FPL− 52694.
Author(s) -
Davies HA,
Rhodes J,
Thomas M
Publication year - 1981
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1981.tb01101.x
Subject(s) - mast cell , secretion , pentagastrin , degranulation , stabiliser , gastric acid , medicine , ingestion , pharmacology , gastric secretion , oral administration , gastroenterology , endocrinology , chemistry , immunology , receptor , food science
1 The effect on gastric acid secretion of a mast cell stabiliser FPL− 52694 was examined in nine healthy volunteers. 2 The compound which is moderately well absorbed after oral ingestion, was taken for 5 days prior to the measurement of acid secretion and was also given intravenously during part of the gastric test. A submaximal dose of pentagastrin (0.3 microgram/kg/h) was given by intravenous infusion for 2 h in a controlled test and then after administration of FPL‐52694. 3 There was a significant reduction (37%) in acid secretion during the second test which was probably due to the effect of the compound on mast cell degranulation in the gastric mucosa.