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Pethidine clearance during continuous intravenous infusions in postoperative patients.
Author(s) -
Austin KL,
Stapleton JV,
Mather LE
Publication year - 1981
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1981.tb01097.x
Subject(s) - pethidine , pharmacokinetics , anesthesia , indocyanine green , medicine , clearance , metabolic clearance rate , body weight , surgery , urology , pharmacology , analgesic
1 Pethidine pharmacokinetics in ten female patients during continuous i.v. infusion for 32 h post‐surgery have been determined. 2 The blood clearance of pethidine (mean +/− 2.d.) measured directly was 599 +/− 135 ml/min and is in marked contrast to some reported values. 3 Other model‐dependent pharmacokinetic parameters were consistent with previously reported values. 4 Pethidine and indocyanine green clearance were correlated but the correlation was mediated through body weight. 5 Pethidine clearance and steady state concentration were predictable retrospectively from linear multivariable equations involving simple physical characteristics of the patient.