Premium
The in vitro metabolism of ethinyloestradiol, mestranol and levonorgestrel by human jejunal mucosa.
Author(s) -
Back DJ,
Bates M,
Breckenridge AM,
Ellis A,
Hall JM,
Maciver M,
Orme ML,
Rowe PH
Publication year - 1981
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1981.tb00534.x
Subject(s) - levonorgestrel , norgestrel , mestranol , endocrinology , medicine , metabolism , population , estrogen , biology , chemistry , research methodology , family planning , environmental health
1 Ethinyloestradiol was extensively metabolised in vitro by human jejunal mucosa to form ethinyloestradiol sulphate. 2 The amount of conjugation was directly related to the weight of biopsy tissue. 3 The degree of conjugation of mestranol and levonorgestrel was much lower than for ethinyloestradiol suggesting that the 17‐position of the steroid nucleus is relatively inaccessible for conjugation. 4 No Phase I metabolism of ethinyloestradiol or levonorgestrel was apparent in the conditions used in these experiments.