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The reliability of 5‐hydroxytryptamine induced platelet aggregation responses in schizophrenic patients treated with neuroleptic drugs.
Author(s) -
Knox JM,
Orr MW,
Allen R,
Gelder MG,
GrahameSmith DG
Publication year - 1981
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1981.tb00531.x
Subject(s) - platelet , platelet aggregation , chlorpromazine , medicine , pharmacology , schizophrenia (object oriented programming) , psychosis , anesthesia , psychiatry
1 The reliability of 5‐hydroxytryptamine induced platelet aggregation responses in psychiatric patients treated with neuroleptic drugs was investigated by examining the effects of a number of technical factors which could account for the variability of responses observed in some patients. 2 Variation in incubation time, temperature, aggregometer stirrer speed, and in the time interval between withdrawal of the blood sample and testing, had no significant effects on the consistency of responses. 3 Dilution of platelet rich plasma (PRP) led to enhanced platelet aggregation responses becoming non‐enhanced. 4 Overcentrifugation of blood samples during the preparation of PRP caused a decrease in the incidence of enhanced platelet aggregation responses observed in chronic schizophrenic patients receiving chlorpromazine. 5 The reliability of platelet aggregation responses as indices of the action of neuroleptic drugs in psychiatric patients remains doubtful.