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THREE YEARS OF EXPERIENCE WITH INDORAMIN
Author(s) -
OLIVEIRA J.M.,
ORTEGARECIO J.C.
Publication year - 1981
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1981.tb00305.x
Subject(s) - diuretic , medicine , hydrochlorothiazide , blood pressure , sedation , anesthesia , supine position
1 One hundred and eight patients were enrolled into an open long‐term assessment of indoramin. All patients were initially treated with indoramin alone. After 6 weeks patients whose blood pressure was not satisfactorily controlled had a diuretic (hydrochlorothiazide) added. If after a further 4 weeks the blood pressure was still not controlled propranolol was added to indoramin and diuretic. 2 Twelve months' treatment were completed by 39 patients on indoramin alone, 32 on indoramin and diuretic and 29 on indoramin, diuretic and propranolol. All treatment groups reduced supine diastolic blood pressure to below 90 mm Hg. 3 Eight patients failed to complete treatment, three being withdrawn from treatment because of side‐effects and five for non‐treatment reasons. 4 The commonest side‐effects were sedation, dry mouth, increase in appetite and failure of ejaculation. Three patients were withdrawn because of this effect but the other patients remained on treatment. All side‐effects were reported in the early weeks of treatment, thereafter the effects appeared to tolerate out. 5 Sixty‐nine patients on indoramin or indoramin and diuretic completed 2 years of treatment and 37 completed 3 years of treatment, the blood pressure being maintained below 90 mm Hg diastolic. A majority of patients were either maintained on the same dose or had the dose reduced.