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ACUTE EFFECTS OF HYDRALAZINE AND INDORAMIN ON RENAL FUNCTION IN MAN
Author(s) -
HENRY J.A.,
OHASHI K.,
WEST C.,
BRITTON K.E.
Publication year - 1981
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1981.tb00298.x
Subject(s) - renal function , effective renal plasma flow , hydralazine , medicine , urology , blood pressure , bolus (digestion) , renal blood flow , anesthesia , supine position
1 Effective renal plasma flow (ERPF), glomerular filtration rate (GFR), supine mean blood pressure (MBP) and pulse rate (PR) were measured in two groups of healthy male volunteers before and after an intravenous bolus injection of hydralazine or indoramin. 2 In six subjects given hydralazine 0.2 mg kg −1 PR rose, BP fell and ERPF rose by 39%. 3 In eight subjects given indoramin 0.25 mg kg 1 there was no significant change in PR, BP, ERPF or GFR. 4 In one subject given indoramin 0.5 mg kg −1 there was a fall in BP and transient anuria. It is possible that an unpredictable response to indoramin may preclude its intravenous use as an acute hypotensive agent. 5 Further studies are required to evaluate the effects of indoramin on renal function when administered long‐term to patients with hypertension and with impaired renal function.