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CLINICAL PHARMACOLOGICAL STUDIES OF INDORAMIN IN MAN
Author(s) -
COLTART JOHN
Publication year - 1981
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1981.tb00295.x
Subject(s) - placebo , blood pressure , medicine , supine position , anesthesia , pharmacology , alternative medicine , pathology
1 The effects of indoramin, a hypotensive drug with competitive α‐adrenergic receptor blocking properties, were studied in a double‐blind investigation in healthy human subjects. 2 Indoramin (20 mg) orally produced a significant fall in blood pressure at high exercise loads when compared with placebo. 3 Indoramin (20 and 40 mg) reduced erect blood pressures during a period of 6 h when compared with placebo in another double‐blind study. 4 Histamine skin wheals were also reduced in a dose‐related manner but no effect on critical flicker frequency was demonstrated. 5 The pressor response to intravenous noradrenaline showed a parallel time‐related shift to the right after the intravenous administration of 20 mg of indoramin. 6 The effect of intravenous indoramin (10 mg) on myocardial function was studied with noninvasive techniques. No effect was demonstrated on systolic time intervals, cardiac output or ejection fraction. 7 Indoramin (20 mg) given orally twice daily for 2 weeks reduced erect and supine blood pressures without evidence of drug accumulation. 8 No drug‐related effects on biochemical or haematologic values were detected.