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Elevated blood histamine levels and mast cell degranulation in solar urticaria.
Author(s) -
Hawk JL,
Eady RA,
Challoner AV,
KobzaBlack A.,
Keahey TM,
Greaves MW
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb05831.x
Subject(s) - histamine , degranulation , mast cell , immunology , medicine , pharmacology , receptor
1 Ultraviolet radiation (UVR)‐induced wealing was studied in four patients with solar urticaria, whose measured action spectra were within the range 300 to 700 nm. 2 Elevated histamine levels were found in blood draining wealed skin in all four patients. 3 Histological and electron microscopial studies of the irradiated skin showed evidence of mast cell degranulation. 4 These findings demonstrate an association between histamine release from mast cells and wealing in solar urticaria, and should encourage evaluation of drugs which suppress histamine release in this disorder.