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Response of pathological ischaemic muscle pain to analgesics.
Author(s) -
Sacchetti G.,
Lampugnani R.,
Battistini C.,
Mandelli V.
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb05828.x
Subject(s) - medicine , placebo , ibuprofen , anesthesia , analgesic , pathological , clinical trial , pharmacology , alternative medicine , pathology
1 Twenty‐four patients suffering from severe pain due to chronic occlusive arterial disease of the legs were given oral doses of indoprofen (200 mg), ibuprofen (300 mg) and placebo. 2 Differences in pain intensity scored on a five‐point scale were taken as measurement of pain relief. 3 This double‐blind, cross‐over trial showed that indoprofen had significantly greater analgesic effect than placebo and reference drug. 4 From a methodological point of view there are many arguments on favour of pathological ischaemic pain as a test for clinical assessment of analgesics.