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The pharmacokinetics of methimazole after oral administration of carbimazole and methimazole, in hyperthyroid patients.
Author(s) -
Skellern GG,
Knight BI,
Low CK,
Alexander WD,
McLarty DG,
Kalk WJ
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb05823.x
Subject(s) - carbimazole , methimazole , pharmacokinetics , medicine , endocrinology , oral administration , antithyroid agent , metabolite , pharmacology , chemistry , graves' disease , thyroid
1 Methimazole plasma concentrations were measured in two groups of hyperthyroid subjects after the oral administration of either carbimazole or methimazole. 2 With the HPLC method it was also possible to measure the concentration of a methimazole metabolite, 3‐methyl‐2‐ thiohydantoin in one patient. 3 Large interindividual differences were observed, especially within the carbimazole group. 4 Incomplete absorption of carbimazole could explain particular high apparent volumes of distribution and apparent clearances.