Premium
Comparison of guanfacine and clonidine as antihypertensive agents.
Author(s) -
Jaattela A.
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb04908.x
Subject(s) - guanfacine , clonidine , medicine , pharmacology , anesthesia
1. The antihypertensive effects and side‐effects of guanfacine and clonidine were compared in a single‐blind, cross‐over study. 2. The study consisted of two active treatment periods of 6 weeks each, which were both preceded by a 2 weeks placebo period. Thirty ambulatory, hypertensive patients (blood pressure WHO severity grades I‐II) were admitted to the study. The results are based on the 24 patients who completed the study. 3. The optimal daily dose of guanfacine was in over half of the patients 3‐4 mg, and of clonidine correspondingly 0.3‐ 0.45 mg. A similar and statistically significant decrease in blood pressure was achieved with both drugs. 4. The most common side‐effects with both drugs were tiredness and dryness of the mouth.