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Pharmacology of guanfacine.
Author(s) -
Scholtysik G.
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb04900.x
Subject(s) - guanfacine , clonidine , medicine , pharmacology , blood pressure , drug , antihypertensive drug , anesthesia
1. The pharmacological effects of the centrally acting antihypertensive drug guanfacine are reviewed. 2. The drug lowers systemic blood pressure in hypertensive rats dose‐dependently after oral application of 0.3‐5 mg/kg. 3. Evidence is presented that guanfacine produces its antihypertensive action by a specific stimulation of central alpha‐ adrenoceptors. 4. Certain pharmacological differences between clonidine and guanfacine are discussed.