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Metabolism of nomifensine (Alival, Merital): isolation and identification of the conjugates of nomifensine‐14C from human urine.
Author(s) -
Hornke I,
Fehlhaber HW,
Girg M,
Jantz H
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb04835.x
Subject(s) - nomifensine , urine , chemistry , metabolism , glucuronide , chromatography , conjugated system , biochemistry , endocrinology , biology , organic chemistry , dopaminergic , dopamine , polymer
1 It can be stated in regard to the metabolism of nomifensine that the metabolites and also the starting compound are present in alkaline urine almost completely in conjugated form. 2 The metabolites M I‐M III represent about 30% of the radioactivity excreted with urine. Two‐ thirds are N‐glucuronides and one‐third O‐glucuronides. 3 Nearly the entire remainder of the renally eliminated radioactivity in nomifensine which is present in conjugated form as N‐glucuronide. 4 Thus over 90% of the metabolites formed in man and excreted via urine have been identified.