Premium
Antipyrine elimination by patients under treatment with monoamine oxidase inhibitors.
Author(s) -
Smith SE,
Lambourn J,
Tyrer PJ
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb04791.x
Subject(s) - phenelzine , monoamine oxidase , monoamine oxidase inhibitor , pharmacology , microsome , oxidase test , chemistry , tranylcypromine , monoamine oxidase b , medicine , enzyme , biochemistry
1 Antipyrine elimination kinetics have been determined in fifteen patients before and after 4 weeks treatment with monoamine oxidase inhibitors and in five patients after treatment only. 2 Antipyrine elimination was slightly but significantly slowed by 28 days treatment with phenelzine but the degree of slowing was uninfluenced by acetylator phenotype or dosage of phenelzine administered. 3 The findings suggest that at the dosage used phenelzine is a weak inhibitor of hepatic microsomal mixed function oxidase in man and it is concluded that this is likely to provide an important source of drug interaction in some patients.