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Use of non‐steroidal anti‐inflammatory drugs in the treatment of pain in cancer.
Author(s) -
Ventafridda V,
Fochi C,
Conno D,
Sganzerla E
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb01820.x
Subject(s) - medicine , adverse effect , cancer , gastrointestinal tract , immune system , pharmacology , neoplastic disease , prostaglandin , disease , immunology
1 Prostaglandins may precipitate or exacerbate pain and they may be produced by several tumours. 2 Non‐steroidal anti‐inflammatory drugs (NSAIDs) inhibit prostaglandin synthesis and may also inhibit bone metastases and enhance immune responses. 3 NSAIDs alone or in association with narcotics or psychotropics may not only afford the best pain relief in neoplastic disease, but also modify the progress of the tumour. 4 The effect of NSAIDs on the gastrointestinal tract is generally adverse.