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Pharmacological evaluation of mild analgesics.
Author(s) -
Romer D
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb01807.x
Subject(s) - ibuprofen , analgesic , antipyretic , pharmacology , potency , medicine , arthritis , adjuvant , anti inflammatory , naproxen , chemistry , in vitro , biochemistry , alternative medicine , pathology
1 The analgesic, anti‐inflammatory, antipyretic and ulcerogenic properties of the non‐steroidal agents, acetylsalicylic acid, paracetamol, ibuprofen, propyphenazone and aminophenazone are compared. 2 The results show that ibuprofen has the most potent effect on all four parameters followed in descending order of potency by aminophenazone, propyphenazone, paracetamol and acetylsalicylic acid. 3 The inflamed paw technique and the adjuvant arthritis model, both in the rat and involving pathological (chronic) pain, are the most successful methods of predicting analgesic activity in man. The short‐ lasting oedema caused by injecting naphthoylheparamine into the rat paw is the most useful method of predicting clinical anti‐inflammatory activity.