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Arachidonic acid metabolism, pain and hyperalgesia: the mode of action of non‐steroid mild analgesics.
Author(s) -
Higgs GA
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb01805.x
Subject(s) - hyperalgesia , bradykinin , prostacyclin , analgesic , prostaglandin , pharmacology , histamine , aspirin , chemistry , arachidonic acid , inflammation , medicine , receptor , arachidonic acid metabolism , nociception , endocrinology , biochemistry , enzyme
1 Cyclo‐oxygenase products such as prostaglandins of the E series and prostacyclin produce the hyperalgesia associated with inflammation. 2 These substances may cause pain and incapacity in some inflammatory conditions. 3 Prostaglandin E2 sensitizes the chemical receptors of afferent pain endings to other inflammatory mediators such as bradykinin and histamine. 4 Unstable intermediates formed in the generation of prostaglandins may also play a role in the production of pain. 5 Drugs such as indomethacin and aspirin which are potent inhibitors of prostaglandin biosynthesis may exert their analgesic effect through this mechanism.