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A comparison of the efficacy of ketotifen (HC 20‐511) with sodium cromoglycate (SCG) in skin test positive asthma.
Author(s) -
Clarke CW,
May CS
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb01791.x
Subject(s) - ketotifen , medicine , asthma , spirometry , anesthesia , sodium cromoglycate , prednisone , cromolyn sodium , sedation
1 Ketotifen (HC 20‐511 Sandoz) 1 mg twice daily for 12 weeks was found to be equivalent to sodium cromoglycate (SCG) 20 mg four times daily for 12 weeks in 35 skin test positive asthmatic patients in a randomised double‐blind cross‐over study. 2 No statistically significant difference between the two drugs in mean values for daily peak flow rates, diary card scores and spirometry at monthly visits was demonstrated. 3 Treatment failures as judged by severe asthma requiring withdrawal from the trial or addition of short courses of prednisone occurred in three patients on each drug. 4 Sedation was noted by 10 patients onHC 20‐511 and 5 on SCG. 5 Weight loss was noted in those patients on SCG, but not those on HC 20‐511.