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Propranolol LA and ambulatory blood pressure.
Author(s) -
Mann S,
Craig MW,
Balasubramanian V,
Raftery EB
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb01786.x
Subject(s) - propranolol , blood pressure , medicine , heart rate , morning , ambulatory blood pressure , ambulatory , regimen , anesthesia , cardiology , surgery
1 The technique of continuous recording of intra‐arterial blood pressure in ambulant hypertensives has been used to investigate the effects of a long‐acting formulation of propranolol (propranolol LA). 2 Seven subjects with untreated essential hypertension were studied before and 2 months after commencing treatment with propranolol LA once daily in the morning, results showing that smooth control of blood pressure and heart rate occurred throughout 24 h. 3 Bicycle ergometry tests performed by these subjects during both studies showed significant blood pressure reduction by propranolol LA during the mild and moderate grades of dynamic exercise. 4 In a parallel study where six treated hypertensives were monitored before and after substitution of standard propranolol by the ‘LA’ form, close correspondence of blood pressure throughout the 24 h occurred with each regimen.