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Drug absorption during physical exercise.
Author(s) -
Aslaksen A,
Aanderud L
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb01774.x
Subject(s) - cmax , sodium salicylate , quinidine , bicycle ergometer , absorption (acoustics) , exertion , pharmacology , drug , medicine , zoology , pharmacokinetics , chemistry , biology , materials science , heart rate , blood pressure , composite material
1 The effect of exercise on the absorption of quinidine sulphate, sodium salicylate and sulphadimidine was studied in healthy volunteers. 2 The study was a randomized cross‐over design with work and rest. The work load was 450 kpm/min for females and 600 kpm/min for males on a bicycle ergometer intermittently for 3 h. 3 The plasma concentrations of the drugs were followed during the entire experiment and their respective peak concentrations (Cmax) and time to peak (tmax) were determined. 4 No significant differences in the Cmax and tmax were found between rest and work for any of the drugs. 5 The results suggest that physical exercise is not a major source of variation in drug absorption.