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Effect of colchicine on polymorphonuclear leucocyte chemotaxis in human volunteers.
Author(s) -
Ehrenfeld M,
Levy M,
Bar Eli M,
Gallily R,
Eliakim M
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb01759.x
Subject(s) - colchicine , chemotaxis , placebo , ingestion , medicine , volunteer , polymorphonuclear leukocyte , pharmacology , gastroenterology , immunology , biology , pathology , in vitro , biochemistry , receptor , alternative medicine , agronomy
1 The effect of colchicine on polymorphonuclear leucocyte chemotaxis was assessed in eight healthy volunteers. Four of them received 1.0 mg colchicine and the other four received placebo daily for 8 successive days. 2 Chemotaxis decreased significantly within 24 h of the ingestion of colchicine; the values remained low throughout the 8 days of treatment and returned to normal within 48 h of cessation of medication. 3 There were no significant changes in the placebo treated subjects.