Premium
Failure of alkaline diuresis to enhance diflunisal elimination.
Author(s) -
BalaliMood M,
Prescott LF
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb01734.x
Subject(s) - diflunisal , diuresis , chemistry , pharmacology , medicine , endocrinology , renal function
1 The effects of alkaline diuresis on the elimination of a single oral dose of 750 mg diflunisal were studied in six healthy male volunteers. 2 The plasma concentrations and half‐life of diflunisal were not reduced by alkaline diuresis. 3 The 72 h urinary recovery of unchanged diflunisal was more than doubled with alkaline diuresis, but even so, only 5‐7% of the administered dose was excreted unchanged. 4 With alkaline diuresis there was a significant increase in the mean renal clearance of diflunisal from 0.27 to 0.46 ml/min, but there was no significant correlation between the renal clearance of diflunisal and urine flow or pH. 5 However, there was a significant increase in the overall mean renal clearance of diflunisal from 0.22 ml/min over the period 0‐24 h to 0.73 ml/min from 48‐72 h. 6 Forced alkaline diuresis is unlikely to be of value in diflunisal poisoning.