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Comparison of plasma and saliva levels of diazepam.
Author(s) -
Gier JJ,
't Hart BJ,
Wilderink PF,
Nelemans FA
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb01732.x
Subject(s) - saliva , diazepam , plasma levels , drug , plasma concentration , pharmacology , chemistry , oral administration , medicine , blood plasma , endocrinology
1 Salivary, unbound and total plasma levels of diazepam have been compared in nineteen subjects. 2 Salivary diazepam levels were significantly higher (P < 0.001) than, but closely related to the corresponding unbound levels (r = 0.97) at 2.5‐3 h after administration of the drug. 3 The results presented suggest that saliva levels can be used to predict the corresponding plasma levels at a given time, but there is no 1:1 relation between the unbound diazepam concentration in plasma and the saliva level of the drug.