Premium
Comparative pharmacokinetics and pharmacodynamics of cardiac glycosides.
Author(s) -
Kelman AW,
Sumner DJ,
Lonsdale M,
Lawrence JR,
Whiting B
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb01730.x
Subject(s) - digoxin , medicine , pharmacokinetics , pharmacodynamics , cardiac glycoside , crossover study , pharmacology , ouabain , glycoside , cardiology , anesthesia , heart failure , chemistry , alternative medicine , organic chemistry , pathology , placebo , sodium
1 The pharmacokinetics and pharmacodynamics of ouabain, digoxinn and beta‐methyl digoxin (medigoxin) have been investigated in a crossover study in four normal healthy volunteers. 2 Pharmacokinetics were studied using [3H]‐labelled glycosides and the shortening of the left ventricular ejection time (LVET) was used as a measure of the effect of the drugs. A graded exercise protocol was used to correct for the effects of heart rate on LVET. 3 In three of the four subjects, both digoxin and beta‐methyl digoxin produced a shortening in the LVET, but no such change could be detected with ouabain in any of the four subjects. 4 There was a good linear correlation between the shortening of the LVET and the amounts of digoxin or beta‐methyl digoxin present in the body tissues. 5 One subject who showed no drug‐related LVET shortening had greatly enhanced clearances of all three drugs studied.