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Blood plasma binding of acebutolol and diacetolol in man.
Author(s) -
Coombs TJ,
Coulson CJ,
Smith VJ
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb01067.x
Subject(s) - acebutolol , pharmacology , blood plasma , medicine , chemistry , blood pressure
1 Acebutolol or diacetolol were added to fresh human plasma in varying concentrations and their extent of binding at 25 degrees C measureed by an equilibrium dialysis technique. 2 The extent of binding for both compounds was shown to be very low, being 11‐19% for acebutolol and 6‐ 9% for diacetolol. 3 Partition coefficients were measured in an n‐ octanol/phosphate buffer (0.05M, pH 7.4) solvent system. For a cebutolol, P = 0.62 and for diacetol, P = 0.08. 4 The very low plasma binding is in accord with the hydrophilic partition coefficients of these compounds.