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Induction of delta‐aminolaevulinic acid synthase in leucocytes of patients on phenytoin therapy‐comparison with changes in rat hepatic tissue.
Author(s) -
McColl KE,
Moore MR,
Thompson GG,
Goldberg A
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb01058.x
Subject(s) - phenytoin , cytochrome p450 , anticonvulsant , peripheral , medicine , endocrinology , atp synthase , cytochrome , enzyme , enzyme inducer , pharmacology , hepatic dysfunction , chemistry , metabolism , epilepsy , biochemistry , psychiatry
1 In rats daily phenytoin (DPH) administration resulted in an increase in hepatic cytochrome P450 content. The rise in cytochrome P450 was associated with a temporary increase in the acitvity of hepatic delta‐ aminolaevulinic acid (ALA) synthase. 2 In patients newly commenced on DPH anticonvulsant therapy the activity of ALA synthase in peripheral leucocytes showed a marked temporary increase during the first 10 days of therapy. 3 These findings suggest that DPH induces a haem‐requiring eenzyme system in peripheral leucocytes as well as in hepatic tissue.