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A study of the effects of atenolol and propranolol on renal function in patients with essential hypertension.
Author(s) -
Wilkinson R,
Stevens IM,
Pickering M,
Robson V,
Hawkins T,
Kerr DN,
Harry JD
Publication year - 1980
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1980.tb00501.x
Subject(s) - atenolol , propranolol , essential hypertension , plasma renin activity , blood pressure , renal function , medicine , endocrinology , mean blood pressure , potassium , labetalol , urology , renin–angiotensin system , pharmacology , chemistry , heart rate , organic chemistry
1 The effects of propranolol and atenolol given in random order in a cross‐over study to fifteen patients with essential hypertension have been studied. 2 Both drugs were effective in lowering blood pressure and side effects were not markedly different. 3 There was no change in exchangeable sodium or potassium or in total body potassium during treatment with either drug. 4 Ambulant plasma renin activity was reduced by both drugs but the fall in blood pressure was not related to initial plasma renin. 5 Despite equal mean reduction in blood pressure with the two drugs, creatinine clearance fell significantly only during treatment with propranolol. 6 These observations suggest that intra‐ renal beta 2‐adrenoceptors may be of importance in the regulation of renal function.