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Concentration effect studies with oral metoclopramide.
Author(s) -
Bateman DN,
Kahn C.,
Davies DS
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb05818.x
Subject(s) - metoclopramide , gastric emptying , sedation , antiemetic , oral administration , placebo , akathisia , absorption (acoustics) , pharmacology , anesthesia , medicine , stomach , dosing , drug , chemotherapy , antipsychotic , schizophrenia (object oriented programming) , alternative medicine , physics , pathology , psychiatry , acoustics , vomiting
1 The effects of single oral doses of 10 mg and 20 mg metoclopramide have been compared to placebo in six normal male volunteers. 2 The drug did not significantly increase the rate of gastric emptying as measured by ethanol absorption. 3 Sedation during the absorption of ethanol was only observed 1 h after the 20 mg oral dose of metoclopramide (P less than 0.05). 4. Akathisia, a central nervous system side effect of metoclopramide, occurred only in subjects who had peak plasma concentrations above 100 ng/ml. 5 It has not been possible to define a concentration‐effect relationship for the action of metoclopramide on the stomach and comparison with previous results after intravenous dosing suggests that the route of administration is of major importance in determining the action of this drug.