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Open evaluation of labetalol in the treatment of angina pectoris occurring in hypertensive patients.
Author(s) -
Besterman EM,
Spencer M
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb04782.x
Subject(s) - labetalol , medicine , angina , ventricle , cardiology , anesthesia , verapamil , chest pain , afterload , blood pressure , calcium , myocardial infarction
1 In nine hypertensive subjects with angina pectoris, labetalol diminished the incidence of chest pain occurring spontaneously or induced by exercise. 2 Labetalol lowered BP in all subjects. 3 Exercise tolerance at maximum levels was increased by labetalol. 4 Improved cardiac function by labetalol may be related to decreased afterload on the left ventricle, and diminished oxygen utilization by the myocardium.