Premium
A multicentre open trial of labetalol in New Zealand.
Author(s) -
Sanders GL,
Davies DM,
Gales GM,
Rao JG,
Rawlins MD,
Routledge PA
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb04777.x
Subject(s) - labetalol , medicine , diuretic , open label , clinical trial , surgery , anesthesia , blood pressure
1 In a multicentre open trial, labetalol was given to 128 patients in ten centres. Forty‐three patients had not previously received antihypertensive therapy; the remainder (85 patients) had been on antihypertensive therapy with either unsatisfactory BP control or troublesome side‐effects. 2 Thirty‐two patients were withdrawn from the trial in the first 6 months of therapy, 24 (19% of the total) because of side‐effects. 3 Control of BP was generally satisfactory or considerably improved. Other drugs (usually a diuretic) had to be added in 23 patients. 4 There was an abnormality of liver function in one patient; otherwise there were no biochemical or haematological problems.