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Mean steady‐state plasma concentrations of labetalol in patients undergoing antihypertensive therapy.
Author(s) -
Sanders GL,
Routledge PA,
Ward A,
Davies DM,
Rawlins MD
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb04772.x
Subject(s) - labetalol , blockade , beta (programming language) , medicine , plasma concentration , anesthesia , antihypertensive drug , alpha (finance) , pharmacology , blood pressure , surgery , patient satisfaction , construct validity , receptor , computer science , programming language
1 Mean steady‐state plasma concentrations of labetalol (labetalol Css) in 17 hypertensive patients undergoing chronic treatment with this drug, have been examined in relation to dose, fall in BP, and beta‐ blockade. 2 A significant relationship (rs = 0.81, P less than 0.001) was observed between labetalol Css and daily dose. 3 No correlation was found between labetalol Css and antihypertensive response. 4 In thirteen patients, there seemed to be significant relationship between labetalol Css and beta‐blockade (rs = 0.72, P less than 0.005). In three patients, the degree of beta‐blockade was disproportionate to the drug concentration.