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Monotherapy with labetalol for hypertensive patients with normal and impaired renal function.
Author(s) -
Thompson FD,
Joekes AM,
Hussein MM
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb04767.x
Subject(s) - labetalol , medicine , renal function , impaired renal function , anesthesia , blood pressure , essential hypertension
1 Labetalol was given to 41 hypertensive patients in a divided dosage of 150–2,400 mg daily for periods ranging from 1–64 months. 2 Monotherapy with labetalol was adequate in 12 out of 19 patients with essential hypertension and in 15 out of the 22 with renal hypertension. 3 Following a single dose of labetalol 200 mg orally a hypotensive response was seen between 1.5 and 2 hours. 4 In the doses used there was no exercise or postural hypotension. 5 No reduction in overall renal function attributable to labetalol was seen.