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Effect of an alpha‐ and beta‐adrenoceptor‐blocking agent (labetalol) on haemodynamics in hypertension.
Author(s) -
Bahlmann J,
Brod J,
Hubrich W,
Cachovan M,
Pretschner P
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb04764.x
Subject(s) - labetalol , medicine , vascular resistance , hemodynamics , vasodilation , forearm , perfusion , anesthesia , peripheral , cardiology , blood pressure , surgery
1 The effect of an intravenous bolus of labetalol (0.6–1.6 mg/kg body weight) on central and peripheral haemodynamics was studied in nine subjects with essential hypertension and in eleven subjects with chronic renal disease and hypertension. 2 The BP reduction amounting to 20/13 mmHg was entirely due to the lowering of the total peripheral vascular resistance. This also included the vascular resistance in the muscles. 3 This peripheral vasodilatation was not counteracted by a reflex increase of the cardiac output. 4 The reflex tachycardia and overshoot of BP in Valsalva's manoeuvre were largely abolished. 5 Central and peripheral venous BPs, vascular volume of the forearm and venous distensibility did not show any significant change after treatment with labetalol. 6 In spite of the lowering of the vascular resistance of the forearm by labetalol, forearm blood flow was not significantly affected due to the parallel decrease in the perfusion pressure. 7 Plasma renin activity fell after labetalol in all instances.