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Impairment of drug metabolism in polycystic non‐parasitic liver disease.
Author(s) -
Sotaniemi EA,
Luoma PV,
Jarvensivu PM,
Sotaniemi KA
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb04714.x
Subject(s) - drug metabolism , endocrinology , drug , liver disease , medicine , metabolism , polycystic liver disease , pharmacokinetics , pharmacology , transplantation , liver transplantation
1. Drug‐metabolizing capacity in cases of polycystic non‐parasitic liver disease was investigated using plasma antipyrine clearance as an index. 2. The four subjects with maternally inherited polycystic liver metabolized antipyrine at a significantly slower rate than the six other members of the family. 3. This reduction in antipyrine metabolism is due to the loss of active liver parenchyma, and is probably also influenced by alterations in the vascular bed due to compression by the enlarged cysts.